What does CTGF do?

CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis.

What is fg3019?

Pamrevlumab (FG-3019) is an experimental therapy being developed by FibroGen to treat pulmonary fibrosis. Pamrevlumab has been granted fast track designation by the U.S. Food and Drug Administration (FDA) for its potential as a treatment.

What do growth factors stimulate?

growth factor, any of a group of proteins that stimulate the growth of specific tissues. Growth factors play an important role in promoting cellular differentiation and cell division, and they occur in a wide range of organisms, including insects, amphibians, humans, and plants.

What is Ctgf Hydrafacial?

HYDRAFACIAL CTGF (Connective Tissue Growth Factor ) Minimizes the appearance of fine lines and wrinkles through naturally derived growth factors. Improves skin health and vitality by bringing skin to a more youthful state.

What is the function of connective tissue growth factor?

Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and tissue fibrosis.

What happens when a growth factor binds?

Once growth factors bind to their receptor, a signal transduction pathway occurs within the cell to ensure the cell is working. Furthermore, in certain cancers, receptors (such as RTKs) are often observed to be overexpressed, which corresponds to the uncontrolled proliferation and differentiation of cells.

Does HydraFacial remove dark spots?

It combines cleansing, exfoliation, extraction, hydration, and antioxidant protection simultaneously, resulting in clearer, more beautiful skin with no discomfort or downtime. HydraFacial™ targets fine lines and wrinkles, congested and enlarged pores, oily or acne-prone skin, hyperpigmentation, and brown spots.

Is a HydraFacial worth the money?

Yes, there is no doubt that the benefits of Hydrafacial Treatment are well worth the cost. On average, HydraFacial costs between $150 and $300. While this seems a little on the high side, it is a small price to pay for such an investment in your skin.

What proteins does CTGF bind to?

In addition, CTGF also binds growth factors and extracellular matrix proteins. The N-terminal half of CTGF interacts with aggrecan, the TSR domain interacts with VEGF, and the CT domain interacts with members of the TGF-β superfamily, fibronectin, perlecan, fibulin-1, slit, and mucins.

What is the mechanism of action of CTGF receptors?

A specific CTGF receptor has not been identified. Instead, CTGF acts via directly binding to integrins and ECM proteins. TGF-β is a potent inducer of CTGF and promotes CTGF expression in fibroblasts, although CTGF can act through TGF-β-independent mechanisms.

What is the ctctgf target gene?

CTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates the deposition of ECM components, including collagen.

What is ctctgf (CCN2)?

CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix -associated heparin -binding proteins (see also CCN intercellular signaling protein ).